Annihilation, along with Decimation and Obliteration, is dropped by Ded Meet when killed during the tutorial, The Supreme Champion. It is also the only Supreme Champion weapon he used out of the three. Although the player is instructed to pick up the three weapons, they could not and the tutorial ends without a chance to use them. However the player is able to use them in the next tutorial, Supreme Weapons. As with Decimation and Obliteration, they can be keepsaked. Players with this version keepsaked kept it when the new version was introduced.