In October 1957, Magaddino was sent, together with his cousin Antonio, to a meeting in Sicily concerning a massive drug network between America and Sicily. The meeting was held at the Grande Hotel Delle Palme in Palermo. The American delegation mainly consisted out of members from the Magaddino and Bonanno family. Not long after that meeting Mangano family boss Albert Anastasia was murdered in New York and Magaddino subsequently became a suspect. Possibly because he was suspected in several crimes, such as bombings, and remained a ghost for many years.