Reina Mayuzumi is the president of Acropolis Pharmaceutical in Trauma Center: Under the Knife 2 who tries to tempt Derek into leaving Caduceus USA to work for her. Reina uses Aletheia, explaining her youthful appearance even though she is really 35. In Mother of Sins and X7, claims that GUILT are "her children". Reina starts by getting Derek to do a puzzle with amino acids and monitoring him during an operation to obtain his Healing Touch to provide the HOA with artificial Healing Touches. Later in the story, Reina is abducted by Delphi, infected with Pempti treated by Derek and Angie.