Lorenzo Nina (May 12, 1812—July 25, 1885) was an Italian prelate of the Roman Catholic Church. A longtime member of the Roman Curia, he served as Prefect of the Congregation for Studies (1877-1878), Vatican Secretary of State (1878-1880), and Prefect of the Congregation of the Council (1881-1885). He was elevated to the cardinalate in 1877.