The Winchester and Potomac Railroad (W&P) was a railroad in the southern United States, which ran from Winchester, Virginia to Harpers Ferry, West Virginia on the Potomac River, at a junction with the Baltimore and Ohio Railroad (B&O). It played a key role in early train raids of the B&O during the beginning months of the American Civil War. The W&P Railroad was acquired by the B&O in 1902, and subsequently became part of CSX Transportation.