This season featured several new guest stars, including Drew Pinsky, Amber Tamblyn, Werner Herzog, Byron Minns, Christopher McCulloch, Samantha Eggar, Pat Healy, Ben Shepard, Laraine Newman, George "Corpsegrinder" Fisher, Cam Pipes, Jon Hamm, Janeane Garofalo, Frankie Ingrassia, Patton Oswalt, Marc Maron, Dweezil Zappa, Kim Thayil of Soundgarden, Andy Richter, Asesino, James Urbaniak, Chris Elliott, and Billy Gibbons of ZZ Top.