Sindone was described as the chief loanshark of Angelo Bruno, suggesting that he may have run a family bank or large scale operation for Bruno. Sindone had previously served time for narcotics trafficking and was heavily involved in illegal gambling within the Philadelphia metropolitan area. Sindone also operated in concert with Philadelphia family associate, Harry D'Ascenzo, who had ties to mobsters in Baltimore. Sindone was made into the Philadelphia family in the early 1970s together with Joseph Ciancaglini. They were the last mob associates to be made into the family under Bruno.