Tsunade (綱手, Tsunade) is one of Konohagakure's legendary Sannin. Though celebrated as the world's most powerful kunoichi and its greatest medical-nin, the repeated loss of her loved ones caused Tsunade to abandon the life of a shinobi for many years. She is eventually persuaded to return to Konoha and becomes its Fifth Hokage (五代目火影, Godaime Hokage, Literally meaning: Fifth Fire Shadow), where her skills proved invaluable to the village.