USS Colhoun (DD-85/APD-2) was a Wickes-class destroyer in the United States Navy during World War I and as APD-2 in World War II. She was the first Navy ship named for Edmund Colhoun. Colhoun was launched 21 February 1918 by Fore River Shipbuilding Company, Quincy, Massachusetts, sponsored by Miss A. Colhoun, commissioned 13 June 1918, Commander B. B. Wygant in command, and reported to the United States Atlantic Fleet.