Nickson won the Lloyds Bank Film Challenge at the age of fourteen with a ten-minute short called Buddha's Legs. She then wrote a half hour comedy for Channel 4 called Life's A Bitch, starring Kathy Burke and Sean Hughes. Two Pints of Lager and a Packet of Crisps was Nickson's first BBC commission and has run for eight years. In April 2010 it was announced that Two Pints was to be refreshed and that Nickson is leaving the production to focus on a number of new solo and collaborative projects in both the UK and America.