Two years after the events of 428: Fūsasareta Shibuya de, Maria Oosawa and Minoru Minorikawa are dispatched as reporters to Shanghai in order to cover the upcoming Shangai NBCR International Anti-Terrorist Conference. Prior to her current assignment, Maria was a victim of a biological attack by unknown terrorists in Shinjuku which resulted in her father saving her life by using an anti-Ua virus vaccine. Maria was saved by her friend, a Middle Eastern girl named Canaan after being targeted for death by masked assassins on her first day in Shanghai after she befriended her in the Middle East prior to her Shanghai trip.