USS Newcomb (DD-586) was a Fletcher-class destroyer in the United States Navy during World War II. She was the only ship named for Commodore Frank H. Newcomb of the United States Revenue Cutter Service, Congressional Gold Medal recipient from the Spanish-American War. Newcomb was laid down 19 March 1943 by Boston Navy Yard; launched 4 July 1943, sponsored by Mrs. C. C. Baughman; and commissioned 10 November 1943, Commander L. B. Cook in command.