In the 2000 Music City Bowl, West Virginia defeated Ole Miss 49–38. This game was also West Virginia Mountaineers football coach Don Nehlen's final game. Although West Virginia won the game, it was notable because of a second half comeback by freshman Eli Manning. Down 49–16 in the fourth quarter, Ole Miss coach David Cutcliffe inserted Manning. Ole Miss scored 22 unanswered points in the fourth quarter.