As part of an ambush on Maquis ships planned in 2370, Federation starships hoped to use the nebula as cover from Maquis sensors. (TNG: "Preemptive Strike" ) According to Star Trek: Star Charts (p. 47) and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the Hugora Nebula was located in the Alpha Quadrant.