Love Lab is set in Fujisaki Girls Academy, which is known for their school body being composed of very proper students. The most prominent one of them is Maki Natsuyo, the student president who is admired by her classmates for her calm and polite demeanor. On the other hand, Riko Kurahashi is also admired but for having a very forward and boyish personality. When Riko discovers a secret about Maki, worlds collide!