Nobushige became an important Takeda general and led large forces on several occasions. In 1544, Shingen had a rebellion on his hands. As part of his punitive effort he sent Nobushige to capture Fujisawa Yorichika's Kōjinyama castle. (He probably succeeded, though sources differ). Katsurao castle, main castle of Murakami Yoshikiyo, fell to Nobushige and Takeda Yoshinobu in 1553. This drove Yoshikiyo to Uesugi Kenshin and was really the last significant act before the start of the Kawanakajima campaigns proper. He was known as one of the "Twenty-Four Generals of Takeda Shingen".