Escadrille SPA.65 of the French Air Force was established during World War I. It was founded at Lyon-Bron Airport on 2 August 1915. Though it was equipped with a mixed bag of aircraft, it was designated as Escadrille C65 for its Caudron G.IVs. It was assigned to VII Armee of the French Army on 24 October 1915. It re-equipped in its entirety with Nieuports, and was redesignated Escadrille N65 on 21 February 1916. In June 1916, it was consolidated into an ad hoc Groupe de Combat that was based at Cachy. Other escadrilles within the Groupe were N3, N37, N62, N73, and N103. In early November 1916, Escadrille N65 was reassigned into Groupe de Combat 13. GC 13 also contained Escadrille N67, Escadrille N112, and Escadrille N.124.