Oxy-Primer is the precursor drug that must be taken before someone can use Oxynate. It clears the lungs of foreign material and increases oxygenation sites. Smokers or others with a high build up of foreign materials in the lungs may need to be hospitalized for oxygen breathing while undergoing the drug due to the coughing fits it generates. Oxy-Primer is manufactured by SMI²LE Pharmaceuticals.