Plankton's cousin, Clem, is visiting Bikini Bottom for a vacation. After finishing the game, SpongeBob SquarePants: Creature from the Krusty Krab, Clem reflects a diabolical idea. Clem diagrams a plan to turn all the Bikini Bottomites into cold, calculating, depraved, bloodthirsty killers, who prey on other Bottomites. With the help of Plankton, Clem creates a medical injection virus that will obliterate brain functions and mutate body cells. The fate of the Pacific Ocean then lies in SpongeBob, Patrick, Sandy, and Mr. Krabs hands.