In 2374, the Honshu was one of sixteen Starfleet vessels assigned to defend the Setlik system against Cardassian forces during the Dominion War. (SCE eBook: War Stories, Book 1) Shortly after, the Honshu was transporting Skrain Dukat to Starbase 621 to stand trial for war crimes when it was attacked by Cardassian vessels and destroyed. (DS9 episode: "Waltz")