Raised in Chicago, Sara Tancredi's ambitions to be a doctor began when she was very young. While at Northwestern University, where she was a Phi Beta Kappa, she was introduced to the works of Mahatma Gandhi and decided to become a humanitarian, which later influenced her decision to work at Fox River State Penitentiary. Another factor which contributed to her occupational choice was her past morphine addiction, culminating in being unable to help a boy after he was run over, because she was high, which was revealed in a flashback episode of the first season, "Brother's Keeper".