Naomi is the younger sister of Hashirama and Tobirama Senju and the older sister of Itama and Kawarama Senju. She was raised in times of war alongside her brothers and would quickly learn to defend herself, utilizing the Wood Release before Hashirama learned to. After seeing Itama and Kawarama fall in war, she made it her goal to prevent as many casualties as possible within her clan, which would lead to her eventually becoming a Medical-nin.