He was a tanner, and lived in the parish of St Margaret's Ipswich, which occupies the area directly to the north of the town centre, outside the medieval earth rampart. The church of St Margaret's stands adjacent to Christchurch Mansion and Park, which was built during Wyl Pyckes' lifetime. The Mansion stood on the site of the former Holy Trinity Priory, one of the two houses of Augustinian canons in the town, which was dissolved and became the property of Sir Thomas Pope (friend of Thomas More, Wolsey's successor as Chancellor), before being demolished to make way for the new brick mansion built by Edmund Withypoll.