Centered in New Orleans, Blood Canticle in narrated by Lestat. The protagonist is a young Mayfair witch named Mona. At the beginning of the novel, Mona is wasting away, victim to a mysterious disease brought on by the birth of her daughter, a so-called Walking Baby. As the novel plays out, Mona and her guardian, Rowan Mayfair, the current designee of the Mayfair legacy, reveal more and more about the powerful genetic plague that has haunted the Mayfairs for generations : the Taltos.