"Handle with Care" is the first track from the Traveling Wilburys 1988 album, Traveling Wilburys Vol. 1, and the group's most successful single. Writing credits are shared by all five band members, George Harrison, Jeff Lynne, Roy Orbison, Tom Petty, and Bob Dylan. The single reached #45 on the Billboard Hot 100 chart, #2 on the Billboard Mainstream Rock Tracks chart, #21 on the UK singles chart and #3 on the ARIA Chart.