In 1504, while visiting her father's lands near Florence, Lisa rescued Ezio after she found him unconscious and laying among the bodies of mercenaries sent by Cesare Borgia that he just killed. While his injuries healed, Ezio stayed in the barn during several days as Lisa hid him and tended to his wounds. During their time together, they developed mutual feelings but due to Lisa's loyalty to her family and Ezio's commitment to the Brotherhood, the Assassin left before anything could happen.