Mainframe appeared in the original G.I. Joe animated series, voiced by Patrick Pinney. In the G.I. Joe Sunbow cartoon 5-part mini series "Arise Serpentor, Arise!", Beach Head and his teammate Mainframe escaped from Cobra troops by hiding in the actual coffin of Vlad Tepes. When they later escape, Mainframe tells Beach Head he wants to talk to him about his deodorant, in which Beach Head replies: "But I don't wear deoderant." "That's what I want to talk to you about," Mainframe responds. In the same series, Mainframe mentioned a posting he had monitoring base security in Vietnam.