Uesugi Tomosada (上杉朝定) (1525–1546), also known as Ōgigayatsu Tomosada (扇ヶ谷朝定), was a samurai commander of the Ōgigayatsu branch of the Uesugi clan around the middle of Japan's Sengoku period. The eldest legitimate son of Uesugi Tomooki of Ōgigayatsu, following his father's death in 1537, though he was still a child, Tomosada led an attack on the Late Hōjō clan in the Tachibana district of Musashi province. He established himself in the temple of Kandai-ji, which he fortified as a castle. Hōjō Ujitsuna took Kawagoe castle soon afterwards from Tomosada's uncle, Uesugi Tomonari, however.