U-8 (short for "Ultimate-8") was a type of bioweapon developed by Tricell through the use of its genetically-altered Plaga parasites, though whether it relied on Type-2 or Type-3 is unknown. This creature was able to give birth to smaller creatures unrelated to the U-8's body design. The U-8 should not be confused with U-3, a creature designed by Los Iluminados several years earlier.