Vincent was born to Luigi and Bedelia Alberti, one of two sons, the other being Nunzio and seven sisters. He stood at 5'2" and weighed 130 pounds. He married Theresa Scialabba in 1949 and fathered one child, Bedelia. He divorced Theresa in 1951 and married Olivia Hughes and fathered two daughters with her, Donna and Olivia. He is the uncle to mobster Jerry Mancuso. In 1963, Government informant Joe Valachi claimed that Squillante participated in the 1957 slaying of Anastasia underboss Frank Scalise. After the murder, Scalise's brother Joe publicly declared that he would avenge Frank's death. However, the Gambino family did not support Joe's declaration, possibly due to Anastasia's opposition. As a result, Joe was forced into hiding for several months until the family ostensibly forgave him