The Illuminados created four Gigantes which were positioned in different locations. US SOCOM agent Leon Kennedy was forced to fight each one of them. The first was brought out from the cult's Plaga mines to kill Leon when he first attempted to free Ashley Graham from her captivity. The beast killed its Ganado handlers and attacked Leon, but Leon recieved unlikely aid in the form of a dog that he had freed from a trap in the woods outside of El Pueblo. The dog leapt down from the hills into the pit where the Gigante was held and distracted the monster so that Leon could open fire on it from behind. After being significantly wounded, the Plaga within the giant's body erupted from its back. Leon fired on the parasite and killed it, which in turn killed the Gigante.