In 2151, while exploring an uncharted M-class planet, several of the crew of Enterprise NX-01 became affected by tropolisine. Doctor Phlox discovered that inaprovaline, combined with being removed from the pollen-saturated environment, would allow the delusional effects of tropolisine to dissipate. (ENT: "Strange New World") Also in 2151, while the crew of the Vahklas was aboard the Enterprise, T'Pol went to bed without meditating. Her dreams were unsettling and she was agitated upon awaking, so she asked Doctor Phlox for 25 milligrams of inaprovaline to calm her nerves. (ENT: "Fusion")