During his reign, King Manuel became allied with the Borgia, the Papal family, often serving their Templar interests. In 1503, Manuel sent Pedro Álvares Cabral to Calicut in India to eliminate the Indian Assassins Guild, but Cabral's attempt was thwarted by a group of Italian Assassins. In response, Manuel sent his prized explorer Vasco da Gama to complete the task, but the subsequent opposition caused Manuel to lose his grip over the city.