In 2154, a Vulcan High Command attack fleet massed in this system in preparation for an abortive preemptive strike against the Andorians. Regulus was the closest accessible star known to be outside the maximum range of Andorian Imperial Guard listening posts. (ENT: "Kir'Shara") A century later, in 2254, Christopher Pike considered retiring and going into business on Regulus or on the Orion colony. (TOS: "The Cage" , "The Menagerie, Part I" ) In 2366, this system was in need of medical supplies, which were transported there by the USS Enterprise-D. (TNG: "The Vengeance Factor" )