Popokarimu appears twice throughout Resident Evil 5, once in the Mining Area, and again in the Caves. In the Mining Area, a cutscene of a Majini driving a steel-plated truck is shown. The truck crashes, killing the Majini, and blocking the path to continue, and Popokarimu jumps out of the vehicle. In the Caves, the Popokarimu flies down from an opening in the ceiling of the statue room. It has a very large amount of health and its shell protects it from gunfire. It has the ability to take flight. While in the air, attacks are virtually useless unless one attacks its vulnerable tail.