Niccolò Coscia (1681 – February 8, 1755) was an Italian Roman Catholic cardinal. He was born at Pietradefusi, near Avellino. In 1725 he was appointed as Cardinal of Santa Maria in Domnica by Pope Benedict XIII, whose secretary he had been when the future pope was Archbishop of Benevento. When Benedict died, Coscia fled Rome. In 1731 he was tried, excommunicated and condemned to ten years' imprisonment in Castel Sant'Angelo. However, he managed to have his sentence commuted to a fine. Restored, he took part to the conclaves of 1730 and 1740. He died in Naples in 1755.