Two-guns is based around the Wild West mission and Mexican Mission due to its design and period similarities to the area of Little Prospect. In the Arcade League If I'm Ugly- You Smell! match he has a one-on-one showdown with Jared Slim, and in the Simian Shootout Challenge, Mikey shoots clay monkeys. Interestingly, his rival Jared Slim returns for future games, whereas Two-guns does not.