USS Hissem (DE-400/DER-400) was an Edsall class destroyer escort of the United States Navy. She was named for Joseph Hissem. Hissem was constructed in 1943 as DE-400. In 1955, the vessel was equipped with modern radars, and the designation was changed to DER-400. The special purpose of DER (Destroyer Escort Radar picket) ships was the detection of aircraft. Their chief role was to extend the DEW line out into the N. Atlantic and the N. Pacific oceans.