Luis Mendes de Vasconcellos (c. 1542 – March 7, 1623) was colonial Governor of Angola, between 1617 and 1621 and the 55th Grand Master of the Order of Malta, between 1622 and 1623. He was born in Évora, Portugal, c. 1542 and died on March 7, 1623 in Malta. He was the son of Francisco Mendes de Vasconcelos (brother of Luís da Costa, a servant of Henrique of Portugal) and wife Isabel Pais de Oliveira, paternal grandson of Cristóvão Nunes da Costa (natural son of Luís Nunes da Costa by Isabel Botelho and brother of Brás Nunes da Costa who had natural issue by Catarina Anes) and wife Catarina Mendes de Vasconcelos and maternal grandson of Paio Rodrigues de Vilalobos and wife Isabel de Oliveira.