Two companies run highway buses to and from Tsukuba. JR and Kanto Tetsudo (also known as Kantetsu) runs various bus services that use the expressways to get you to distant places quickly. There are two (identical) bus services to and from Tokyo. * JR Highway Bus * Kanto Tetsudo Highway Bus The time to go between Tokyo Main Station and Tsukuba Station is about 2 hours. A timetable with both companys can be found here. * Timetable