It started off when years ago, there was a magic potion created by Calamitous that can make you go to other dimensions. So after all the failures in the Nicktoons world. He goes by a waterfall and pour some potion into it and him and the Evil Syndicate jumps in. So eventually all the Nicktoons finds out, and Frankie bought some newcomers from his show, Chuck, Perry, & Kevin, to come along with them and join them on their adventures, so they all jumps in and goes to the real world, but wind up in New York. And they have to stop the Evil Syndicate from taking over the real world.