The Colt M-16A1 is a custom version of the Colt M-16 and is the primary weapon of Michael Franklin Miller who utilizes it on his missions against hordes of the undead and the Umbrella Corporation. He has made it to utilize a new ammunition type, the 7.92x45mm and 7.62x45mm NATO which is very accurate and deadly to anyone that is hit by it. If Miller ever runs out of ammo for either this weapon or his STG-44, he always has his dual Colt M1911 pistols and a Remington Double Barreled shotgun on his back.