A full aircraft is flying out of Los Angeles International Airport at night, heading east to Boston. Later in the flight, Dinah Bellman, a blind girl, awakens and asks her aunt for water. When she gets no response, she calls for help, but only Brian Engle, an airline pilot who is a passenger on this flight, awakens to Dinah's call for help. Other passengers then begin to rise up out of their seats. The mystery begins when these nine people discover they are the only ones left on the plane; not even the pilots are aboard. Brian and Nick Hopewell, a mysterious British man, discover the plane is on autopilot.