Spy6teen began as a contestant in DC COMICS now defunct webcomic initiative, Zuda. After the folding of the imprint, the team continued the story, intending to release it as a print comic; but seeing the opportunities available in the digital realm, elected to instead distribute in the webcomic realm. The comic follows the adventures of Cally Calhoon, a model high school student who moonlights as an international spy. Difficulties arise as she realizes her two worlds are merging, despite her attempts to maintain a "normal" life.