Little Sister is a song by Queens of the Stone Age. Lead singer Josh Homme says that this song inspired by the "sort of sexual twist" of the song "Little Sister," which Elvis Presley recorded in 1961. The song was recorded in one take. Queens of the Stone Age performed this on Saturday Night Live. Will Ferrell, who was hosting the show, joined the band onstage and played the cowbell dressed as his character from the famous "More Cowbell" sketch, which parodied the usage of the cowbell in Blue Oyster Cult's "Don't Fear the Reaper." The Cowbell sound in the song is actually a Jam Block.