Latino Malabranca Orsini (b. at Rome, year unknown – d. August 10, 1294, Perugia) was an Italian Cardinal-nephew of Pope Nicholas III. He was son of Roman senator Angelo Malabranca and Mabilia Orsini, sister of Pope Nicholas III. He entered the Order of Preachers in his youth and studied law at University of Paris. He obtained the titles of doctor in law and maestro in theology. Then he became prior of the Dominican convent of S. Sabina in Rome and definitor of the provincial chapter in Orvieto. On March 12, 1278 he was created Cardinal-Bishop of Ostia e Velletri by his uncle Pope Nicholas III (1277-1280). At that same time he was named Inquisitor General and head of the Papal Inquisition; he succeeded his uncle in this post and occupied it until death. Vicar and governor of Rome during ab