During my long and intimate acquaintance with Mr Sherlock Holmes I had never heard him refer to his relations, and hardly ever to his own early life. This reticence upon his part had increased the somewhat inhuman effect which he produced upon me, until sometimes I found myself regarding him as an isolated phenomenon, a brain without a heart, as deficient in human sympathy as he was pre-eminent in intelligence. His aversion to women and his disinclination to form new friendships were both typical of his unemotional character, but not more so than his complete suppression of every reference to his own people. I had come to believe that he was an orphan with no relatives living, but one day, to my very great surprise, he began to talk to me about his brother.