HMS E52 was a British E class submarine ordered from Yarrow Shipbuilders, Scotstoun but was transferred on 3 March 1915 to William Denny and Brothers, Dumbarton. She was laid down on 25 January 1917 and was commissioned on an unknown date. HMS E52 sank the U-boat UC-63 near the Goodwin Sands, Dover Straits on 1 November 1917. HMS E52 was sold on 3 January 1921 in Brixham.