James Wilson Holsinger, Jr., (born May 11, 1939 in Kansas City, Kansas) is an American physician. A former major general in the U.S. Army Reserve (1962 to 1993), he has worked primarily in public health for over thirty years. He served as the Under Secretary of Veterans Affairs for Health from 1990 to 1993, during the administrations of George H. W. Bush and Bill Clinton. From 1994 to 2003, Holsinger was the Chancellor of the University of Kentucky's Chandler Medical Center. From 2003 to 2005 he served as Kentucky's Secretary of Health and Family Services.