The most common stress that living organisms constantly confront in nature is likely to result from temperature changes. Cold-shock research is a hot topic and its further advancement will not only yield new exciting discoveries with respect to biological function, but will also aid the improvement of human health and to the energy conservation of households. Cold-water stepping, dew walking, dry brushing and lymph drainage are all useful in stimulating the skin. Exposure to cold water activated cellular immunity, while warm water activated humoral immune system. [[]